FBD has extensive experience working with
for Target Validation, Lead Generation and Lead Optimisation projects.
- established CAMD (Computer Aided Molecular Design)teams
- and providing an outsourced facility for chemistry and biology groups
In-house proprietary software, Bodil, provides new cutting-edge techniques
for Homology studies. Where required these can be complemented by structural determination through
Protein X-ray crystallography.
Using Structure Based Drug Design techniques, pharmacophore models are developed to explain the protein-ligand
interaction and the binding mode of the drug target. These results are suitable for use in virtual screening
against corporate databases, or comprehensive collections of commercially available compounds.
Custom library design can provide alternative core structures for chemists to develop providing access to
patentable areas of IP or increasing the binding affinity by log points. FBD can also provide chemical samples
with which to test the hypothesis generated and provide some real datapoints to minimise the iterative process.